Table 2.
Pharmacokinetic parameters for DPX PMs and DPX commercial tablets in the plasma and brain
| Parameter | Tmax (h) | Cmax (ng/mL) | AUC0–inf_obs (ng h/mL) | MRT (h) |
|---|---|---|---|---|
| Plasma | ||||
| DPX PMs formula (F3) | 6.4±0.5* | 458.84±45.3* | 6,061.36±212.3* | 9.46±1.1 |
| Commercial DPX tablets | 1.2±0.2 | 624.8±50.1 | 2,214.2±132.1 | 7.4±1.2 |
| Brain tissue | ||||
| DPX PMs formula (F3) | 1.5±0.3* | 242.96±21.1 | 2,571.35±118.6* | 10.86±2.1 |
| Commercial DPX tablets | 0.97±0.2 | 216.9±11.2 | 1,337.63±99.21 | 9.21±1.5 |
Note:
*
Significant at P<0.05 using Student’s t-test.
Abbreviations: AUC, area under the curve; DPX, dapoxetine; MRT, mean residence time; PMs, polymeric micelles; Cmax, maximum DPX plasma concentration; Tmax, time to reach this concentration.