Figure 2.

Host-plant effects on differential expression and methylation of key aphid genes that complement and regulate the integrated aphid-Buchnera amino acid metabolism. Gene boxes are annotated with either E.C. numbers, Genbank LOC numbers, and/or gene names. Genes are significantly up-regulated in bacteriocytes compared to body cells (BAC vs. BODY) and enriched in alfalfa compared to fava bacteriocytes (ABAC vs. FBAC) if adjusted p-value ≤ 0.05 and normalized read counts are 50% higher. Genes are differentially methylated significantly if there was ≥10% difference in percent methylation and FDR corrected p-value ≤ 0.01.