Fig. 4.

Structure of human SR-B1, both as a monomer and as a dimer. The monomer and dimer forms of human SR-B1 were built separately through homology modeling using MODELLER (246). From 200 generated models, the top ranked models were chosen for energy minimization through Amber molecular dynamics simulation (247). The energy-minimized structures were used for the structural analysis. The residues comprising the tunnel cavity are labeled, and the regions where conformational differences are observed between monomers and dimers are highlighted in yellow squares.