TABLE 3.

Cox models (end-point cardiovascular events/all cause death)

	Model 1		Model 2		Model 3		Model 4
	HR (CI 95%)	P	HR (CI 95%)	P	HR (CI 95%)	P	HR (CI 95%)	P
Continuous predictors
HDL-C (mg/dl)	0.987 (0.976–0.997)	0.014	1.001 (0.990–1.013)	0.836	1.006 (0.994–1.018)	0.334	1.002 (0.990–1.013)	0.749
logSAA (μg/ml)	1.699 (1.201–2.402)	0.003	1.443 (1.037–2.009)	0.030	1.416 (1.026–1.954)	0.034	1.018 (0.666–1.556)	0.935
Paraoxonase activity (U/ml)	0.997 (0.995–0.998)	<0.001	0.999 (0.998–1.001)	0.309	1.000 (0.998–1.001)	0.760	1.000 (0.998–1.002)	0.899
Antioxidative activity (inhibition of oxidation, %)	1.014 (0.985–1.045)	0.340	0.997 (0.967–1.028)	0.837	1.002 (0.972–1.033)	0.885	1.007 (0.976–1.039)	0.664
Lp-PLA2 activity (U/ml)	0.997 (0.984–1.011)	0.688	1.003 (0.990–1.017)	0.629	1.009 (0.996–1.022)	0.196	1.010 (0.997–1.023)	0.133
Categorized predictors
HDL-C
1st tertile		0.017		0.276		0.308		0.316
2nd tertile	0.682 (0.469–0.991)	0.045	0.739 (0.499–1.094)	0.131	0.750 (0.505–1.112)	0.152	0.786 (0.530–1.165)	0.230
3rd tertile	0.587 (0.395–0.871)	0.008	0.970 (0.499–1.094)	0.895	0.967 (0.614–1.525)	0.886	1.071 (0.675–1.699)	0.771
SAA
1st tertile		0.051		0.079		0.052		0.423
2nd tertile	1.283 (0.851–1.936)	0.234	1.526 (1.006–2.314)	0.047	1.562 (1.029–2.372)	0.036	1.323 (0.850–2.060)	0.215
3rd tertile	1.633 (1.099–2.428)	0.015	1.512 (1.007–2.269)	0.046	1.587 (1.053–2.392)	0.027	1.123 (0.673–1.873)	0.658
Paraoxonase activity
1st tertile		<0.001		0.790		0.613		0.570
2nd tertile	0.549 (0.375–0.806)	0.002	0.874 (0.584–1.308)	0.512	0.940 (0.625–1.414)	0.768	1.040 (0.686–1.578)	0.853
3rd tertile	0.477 (0.323–0.704)	<0.001	0.905 (0.597–1.370)	0.636	1.173 (0.751–1.830)	0.483	1.259 (0.803–1.946)	0.316
Antioxidative activity
1st tertile		0.406		0.583		0.623		0.367
2nd tertile	0.818 (0.542–1.235)	0.340	0.806 (0.531–1.222)	0.309	0.814 (0.536–1.235)	0.333	0.756 (0.497–1.150)	0.191
3rd tertile	1.058 (0.719–1.557)	0.774	0.864 (0.580–1.288)	0.473	0.915 (0.613–1.367)	0.666	0.956 (0.640–1.428)	0.827
Lp-PLA2 activity
1st tertile		0.852		0.634		0.353		0.210
2nd tertile	0.896 (0.606–1.324)	0.581	1.218 (0.812–1.828)	0.340	1.280 (0.852–1.922)	0.235	1.384 (0.919–2.086)	0.120
3rd tertile	0.929 (0.632–1.365)	0.707	1.105 (0.774–1.641)	0.620	1.310 (0.872–1.967)	0.193	1.367 (0.910–2.054)	0.132

Model 1: univariate analysis. Model 2: Model 1 adjusted on age, gender, BMI, mean blood pressure, current smoking, diabetes mellitus, eGFR, and log-transferred albuminuria. Model 3: Model 2 with additional adjustment for total cholesterol and HDL-C (for analyses with SAA, antioxidative activity, paraoxonase activity and Lp-PLA₂ activity as exposition variable), respective logSAA (for analyses with HDL-C and effective HDL-C as exposition variable). Model 4: Model 3 with additional adjustment for CRP. Boldface type indicates significance (P < 0.05).