Table 1.
Worsening of 40 conditions caused by the lack of physical activity with growth, maturation, and aging throughout life span
| 1. Accelerated biological aging/premature death |
| 2. Aerobic (cardiorespiratory) fitness (VO2max) |
| 3. Arterial dyslipidemia |
| 4. Balance |
| 5. Bone fracture/falls |
| 6. Breast cancer |
| 7. Cognitive dysfunction |
| 8. Colon cancer |
| 9. Congestive heart failure |
| 10. Constipation |
| 11. Coronary (ischemic) heart disease |
| 12. Deep vein thrombosis |
| 13. Depression and anxiety |
| 14. Diverticulitis |
| 15. Endometrial cancer |
| 16. Endothelial dysfunction |
| 17. Erectile dysfunction |
| 18. Gallbladder diseases |
| 19. Gestational diabetes |
| 20. Hemostasis |
| 21. Hypertension |
| 22. Immunity |
| 23. Insulin resistance |
| 24. Large arteries lose more compliance with aging |
| 25. Metabolic syndrome |
| 26. Nonalcoholic fatty liver disease |
| 27. Obesity |
| 28. Osteoarthritis |
| 29. Osteoporosis |
| 30. Ovarian cancer |
| 31. Pain |
| 32. Peripheral artery disease |
| 33. Preeclampsia |
| 34. Polycystic ovary syndrome |
| 35. Prediabetes |
| 36. Rheumatoid arthritis |
| 37. Sarcopenia |
| 38. Stroke |
| 39. Tendons being less stiff |
| 40. Type 2 diabetes |
The breadth of the list implies that a single molecular target will not substitute for appropriate daily physical activity to prevent the loss of all listed items.