Figure 6.

MiR-370 modulates the sensitivity of cancer cells to IFN-$\alpha$ induced apoptosis in vivo. (A) Xenograft tumors were induced in NOD/SCID mice by implantation of Huh7 or LH86 cells infected with an adenovirus expressing miR-370, and the mice were treated with IFN-$\alpha$ every 3 days thereafter. (B) The mice were sacrificed 42 days after HCC cell implantation and the tumor volume was calculated. The volumes of the (C) LH86 derived and (D) Huh7 derived tumors were compared with the control virus. The data presented are representative of 3 independent experiments.