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. 2018 Jul 2;5(3):ENEURO.0153-18.2018. doi: 10.1523/ENEURO.0153-18.2018

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Copyright © 2018 Kononoff et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Intra-habenular but not intra-IPN JNJ-63533054 administration decreases alcohol intake and increases paw withdrawal thresholds in alcohol-dependent rats during withdrawal. A, Timeline of microinfusions of JNJ-63533054 in alcohol-dependent rats. B, Intra-habenular infusion of JNJ-63533054 (0.25 µg/0.5 µl) decreased alcohol self-administration in dependent rats (**p < 0.01), without affecting water self-administration (n = 6). C, Intra-habenular infusion of JNJ-63533054 increased paw withdrawal thresholds during alcohol withdrawal (**p < 0.01). D, Histology of accurate injection sites in the habenula (black circles) and misplaced injection sites (white circles); 5× magnification. E, In situ hybridization of GPR139 receptors in mouse habenula. Modified from Allen Mouse Brain Atlas (AllenMouseBrainAtlas, 2004). F, Intra-IPN infusion of JNJ-63533054 did not affect alcohol or water self-administration in alcohol-dependent rats (n = 7). G, Paw withdrawal thresholds during alcohol withdrawal were unaffected by intra-IPN infusion of JNJ-63533054. H, Histology of accurate injection sites in the IPN (black circles) and misplaced injection sites (white circles); 2.5× magnification. I, In situ hybridization of GPR139 receptors in the mouse IPN. Modified from Allen Mouse Brain Atlas (AllenMouseBrainAtlas, 2004). cp, cerebral peduncle; DG, dentate gyrus; D3V, dorsal third ventricle; LHb, lateral habenula; MHb, medial habenula; ml, medial lemniscus; SN, substantia nigra; VTA, ventral tegmental area.