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. Author manuscript; available in PMC: 2018 Dec 20.
Published in final edited form as: Nature. 2018 Jun 20;558(7711):620–623. doi: 10.1038/s41586-018-0241-9

Figure 1. Overall cryo-EM reconstruction of the 5-HT1BR–GO heterotrimer complex.

Figure 1

The density for the cryo-EM map (sharpened with a B factor of -200) is coloured according to the subunit. The inset shows the orthosteric binding pocket in 5-HT1BR (light blue) with donitriptan depicted as sticks (green, carbon) and its density in the cryo-EM map. The lower panel shows a superposition of ergotamine-bound 5-HT1BR (pale grey, PDB ID 4IAR)15 and donitriptan-bound 5-HT1BR (pale blue). Donitriptan (green, carbon) and ergotamine (orange, carbon) are depicted as sticks.