Figure 2.
Diagram illustrating dynamic relationships between small vessel function, and SVD lesions. A, Resting CBF is weakly related to intracranial vascular pulsatility but not to cerebrovascular reactivity while increasing pulsatility is strongly related to declining cerebrovascular reactivity. B, falling CBF is not related to WMH or PVS severity, but both increasing pulsatility and falling cerebrovascular reactivity are associated with increased WMH and PVS. C, Close inspection of FLAIR (top) and T2-weighted (bottom) MRI shows that WMH form around PVS.