. Author manuscript; available in PMC: 2018 Jul 10.

Published in final edited form as: Sci Transl Med. 2018 Jan 10;10(423):eaai7795. doi: 10.1126/scitranslmed.aai7795

Table 3.

Subphenotypic values by LRRK2 N2081D and R1398H genotype in pooled Ashkenazi Jewish and non-Jewish CD cohorts

N2081D genotype	Age of CD onset (SD) [N]	Disease location in ileum [N]
AA	26.5 (14.0) [5601]	80.5% [5311]
GA	24.6 (13.1) [482]	86.1% [453]
GG	20.8 (9.0) [12]	90.9% [11]
	P=0.002	P=0.01

R1398H genotype
GG	26.3 (13.9) [5365]	81.1%[5095]
GA	26.4 (14.1) [701]	80.7% [652]
AA	27.2 (19.4) [29]	71.4% [28]
	ns	ns

SD, standard deviation. N, group sample size. ns, not significant. Similar results were found for the N551K variant (in strong linkage disequilibrium with R1398H, r²=0.81). P values were calculated using simple linear regression.