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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Cancer Res. 2018 Apr 26;78(12):3375–3385. doi: 10.1158/0008-5472.CAN-17-3464

Figure 4.

Figure 4

Associations between DNA methylation and gene expression in head and neck squamous cell carcinoma (HNSC). (A) Genome-wide plot of smoothed gene-level Pearson correlation coefficients between binary DNA methylation measurements and gene expression for n = 250 HNSC samples. (B) Plot of smoothed gene-level Pearson correlation coefficients between binary DNA methylation measurements and gene expression for n = 250 HNSC samples in chromosome 19. (C – E) Boxplot displays of expression values of select zinc finger genes by DNA methylation status illustrate strong regulation of gene expression by DNA methylation.