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. Author manuscript; available in PMC: 2018 Jul 2.
Published in final edited form as: Cell Rep. 2016 Jan 21;14(5):1025–1031. doi: 10.1016/j.celrep.2015.12.098

Figure 3. Model for effect of divergent and convergent transcription.

Figure 3

A. As RNAP2 complexes converge, positive supercoiling builds up that is relieved by the type II topoisomerase activity of Top2. B. As RNAP2 complexes move away from each other in a divergent orientation, negative supercoiling is generated between them resulting in localized DNA melting and ssDNA formation, increasing the risk for damage to the DNA by endogenous or exogenous sources.