Table 1.
GCR rate in indicated background with no galactose-induced promoters at the assay locus1
| Genotype | GCR Rate2 × 10−10 |
|---|---|
| Wild-type | < 0.79 |
| top1Δ | 0.80 |
| top3Δ | 320 (130–890) |
| top2-1 | 41 |
1
Cells were still cultured in galactose, but neither the GAL1 nor GAL2 promoter sequences are present at the GCR testing locus.
2
Rates determined by method of the median have the 95% confidence interval indicated in parentheses. All other rates were determined by Luria-Delbrück fluctuation analysis (see Methods).