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. 2018 Jun 22;37(13):e99875. doi: 10.15252/embj.201899875

Figure 1. The mammalian non‐coding RNA response to infections by the pathogenic bacterium Salmonella .

Figure 1

Host cells utilize microRNAs (e.g., let‐7, miR‐15, miR‐30, miR‐128, miR‐146, miR‐155) and lncRNAs (e.g., NeST) to respond to Salmonella infection. Imamura et al (2018) now report loss of nuclear RNA degradation factors and accumulation of unstable nuclear lncRNAs in response to intracellular Salmonella growth. These lncRNA candidates may contribute to host defense mechanisms that help clear the invading pathogen.