Figure 1.

Schematic representation of the interleukin (IL)-12 cytokine family and their receptors, and associated Janus kinase and signal transducers and activators of transcription (JAK-STAT) signaling partners. (A) Current members of the IL-12 family with defined physiological function. (B) Potential new members of the IL-12 cytokine family that can be generated following subunit pairing. Ebi3, Epstein–Barr virus-induced gene 3 protein (also known as IL-27β); IL-12R, IL-12 receptor; IL-23R, IL-23 receptor; TYK2, tyrosine kinase 2.