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. 2018 Jul;10(7):a029413. doi: 10.1101/cshperspect.a029413

Figure 1.

Figure 1.

Diagram of the contact footprint of three hemagglutinin (HA) stem-binding antibodies with different influenza subtype specificity. Shown is the HA stem (highlighted by the black box on the diagram of whole HA on the far left) with two potential glycans shown in green. Group 1 HA has a glycan at N21, while group 2 HA is glycosylated at N38. Antibodies that bind the group 1 HA stem (left) have a contact footprint (shown in orange) that avoids the N21 glycan. Group 2 HA stem-binding antibodies (center, CR8020 contact footprint shown in purple) avoid the N38 glycan. Cross-group HA stem-binding antibodies (right, contact footprint of FI6 shown in light green) are able to bind in the presence of either glycan. Diagrams are based on published structural data (Ekiert et al. 2009; Sui et al. 2009; Corti et al. 2011; Dreyfus et al. 2012).