Table 1. Basic information on the in vivo experimental models used to test the effects of E. oleracea.

Model	Animals	Interventions	Referencesa	QATRS
Cancer	Male F344 rats	Esophageal carcinogenesis induced by NMBA	Stoner et al. 2010	16
	Male Swiss mice	Urothelial carcinogenesis induced by BBN and MNU	Fragoso et al. 2012	20
	Male Wistar rats	Colon carcinogenesis induced by DMH	Fragoso et al. 2013	20
	Male Wistar rats	Anorexia-cachexia syndrome induced by Walker-256 tumor	Nascimento et al. 2016	16
	Male ICR mice	Colon carcinogenesis induced by AOM and DSS	Choi et al. 2017	16
	Female C57BL/6 mice	Melanoma induced by transplantation of B16F10 cells	Monge-Fuentes et al. 2017	18
Toxicity	Male Swiss mice	DNA damage induced by doxorubicin	Ribeiro et al. 2010	18
	Male Wistar rats	DNA damage induced by doxorubicin	Marques et al. 2016	18
	BALB/c mice	DNA damage induced by cyclophosphamide	Schauss et al. 2010a	18
	Wistar rats	Acute and subchronic oral toxicity study	Schauss et al. 2010a	18

AOM = azoxymethane; BBN = N-butyl-N-(4-hydroxybutyl)-nitrosamine; B16F10 = melanoma cell lines; DSS = dextran sulfate sodium; DMH = 1,2-dimethylhydrazine; ICR = International Cancer Research; MNU = N-methyl-N-nitrosourea; NMBA = N-nitrosomethylbenzylamine.

^aA reference can have more than one model of disease.