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. 2018 Jul;28(7):1039–1052. doi: 10.1101/gr.226282.117

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© 2018 Kong et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — The results of sequencing skin biopsy samples from each side of the body of a child with hemihyperplasia. Results from the normal side are shown on the left and from the overgrown side on the right. Exome sequencing to ∼100× mean coverage indicates a model of mosaic trisomy 12 of mitotic origin in 6.8% of cells, while the more targeted (multi-ethnic) meMAD-seq capture assay (described later) sequenced to a comparable depth shows evidence for the same type of mosaicism in 5.4% of cells.