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Schematic to illustrate how the amount of headgroup hydration (depicted in blue) and the space for water to move around the headgroups depends on the size and concentration of molecular species. Little space is available around headgroups in a pure DSPC bilayer (a), whereas space around the headgroups becomes accessible to water when ISIS molecules are present (b) or to a lesser extent when short (c) or long (d) alcohol molecules are added.
