Table 2.
Univariate Cox Regression Analysis for Recurrence and Death After Lung Cancer Surgery.
| Variable | Recurrence | 95% Confidence Interval | P Value | Death | 95% Confidence Interval | P Value | ||
|---|---|---|---|---|---|---|---|---|
| HR | Lower | Upper | HR | Lower | Upper | |||
| Female (vs male) | 0.860 | 0.653 | 1.133 | .284 | 0.524 | 0.414 | 0.663 | <.001 |
| Age, years | 1.000 | 0.990 | 1.016 | .654 | 1.050 | 1.034 | 1.058 | <.001 |
| Body mass index, kg/m2 | 1.040 | 0.995 | 1.093 | .082 | 0.929 | 0.894 | 0.965 | <.001 |
| ASA | ||||||||
| 1 | 1.000 | 1.000 | ||||||
| 2 | 1.380 | 1.003 | 1.912 | .048 | 1.430 | 1.102 | 1.862 | .007 |
| 3 | 1.210 | 0.744 | 1.975 | .441 | 2.070 | 1.470 | 2.925 | <.001 |
| Histologic type | ||||||||
| Squamous cell carcinoma | 1.000 | 1.000 | ||||||
| Adenocarcinoma | 0.708 | 0.533 | 0.941 | .018 | 0.549 | 0.437 | 0.689 | <.001 |
| Othersa | 0.268 | 0.146 | 0.495 | <.001 | 0.691 | 0.498 | 0.958 | .027 |
| Type of operation I | ||||||||
| VATS | 1.000 | 1.000 | ||||||
| Open thoracotomy | 2.160 | 1.664 | 2.813 | <.001 | 2.040 | 1.659 | 2.520 | <.001 |
| Type of operation II | ||||||||
| Lobectomy | 1.000 | 1.000 | ||||||
| Segmentectomy | 0.000 | 0.000 | Inf | .992 | 0.322 | 0.133 | 0.780 | .012 |
| Wedge resection | 0.314 | 0.155 | 0.636 | .001 | 0.593 | 0.385 | 0.913 | .018 |
| Hypertension | 1.220 | 0.860 | 1.730 | .266 | 0.844 | 0.610 | 1.167 | .305 |
| Diabetes mellitus | 1.410 | 0.870 | 2.280 | .164 | 1.140 | 0.730 | 1.770 | .570 |
| Stroke history | 0.768 | 0.362 | 1.630 | .492 | 1.080 | 0.622 | 1.888 | .777 |
| IHD history | 0.795 | 0.392 | 1.609 | .523 | 1.100 | 0.653 | 1.842 | .727 |
| Tumor | ||||||||
| 0-1 | 1.000 | 1.000 | ||||||
| 2 | 3.970 | 2.829 | 5.570 | <.001 | 2.070 | 1.641 | 2.623 | <.001 |
| 3 | 7.540 | 4.794 | 11.866 | <.001 | 3.490 | 2.412 | 5.051 | <.001 |
| 4 | 7.930 | 4.765 | 13.213 | <.001 | 5.660 | 3.894 | 8.229 | <.001 |
| Node | ||||||||
| 0 | 1.000 | 1.000 | ||||||
| 1 | 79.500 | 43.758 | 144.413 | <.001 | 2.080 | 1.606 | 2.695 | <.001 |
| 2 | 105.000 | 57.658 | 192.847 | <.001 | 2.920 | 2.236 | 3.816 | <.001 |
| Adjuvant radiotherapy | 3.146 | 2.389 | 4.143 | <.001 | 3.063 | 2.453 | 3.825 | <.001 |
| Adjuvant chemotherapy | 2.299 | 1.135 | 4.660 | .021 | 2.293 | 1.317 | 3.994 | .003 |
| Surgery time, minutes | 1.004 | 1.002 | 1.005 | <.001 | 1.004 | 1.003 | 1.005 | <.001 |
| Anesthesia time, minutes | 1.004 | 1.003 | 1.006 | <.001 | 1.004 | 1.003 | 1.006 | <.001 |
Abbreviations: ASA, American Society of Anesthesiologists; IHD, ischemic heart disease; HR, hazard ratio; VATS, video-assisted thoracic surgery.
a Others: large cell type, sarcomatoid lung cancer.