Table 1. Genes comprising the orange3 candidate module for both alcohol clearance and acetate AUC.

The candidate module was identified based on eigengene association (nominal p-value < 0.01) with the phenotypes across the HXB/BXH panel and a maximum module eigengene quantitative trait locus that was both significant (genome-wide p-value < 0.01) and overlapped significant (genome-wide p-value < 0.05) or suggestive (genome-wide p-value < 0.63) phenotypic quantitative trait loci for the phenotypes in the HXB/BXH RI rat panel after 2 g/kg alcohol administration. Genes are ordered by intra-modular connectivity.

Associated Gene Name	Chromosome	Gene Starting Position (Mb)	Type	Description	Intra-modular Connectivity
Adh4	2	243.70	Protein coding	Alcohol dehydrogenase 4 (class II)	1.18
Adh1	2	243.55	Protein coding	Alcohol dehydrogenase 1 (class I)	1.17
Hs2st1	2	250.47	Protein coding	Heparan sulfate 2-O-sulfotransferase 1	1.14
Arl16	10	109.64	Protein coding	ADP-ribosylation factor-like 16	1.13
Gbp5	2	248.18	Protein coding	Guanylate binding protein 5	1.11
Camk2n1	5	156.88	Protein coding	Calcium/calmodulin-dependent protein kinase II inhibitor 1	1.11
LOC685067	2	248.22	Protein coding	Similar to guanylate binding protein family, member 6	1.10
Tmem79	2	187.70	Protein coding	Transmembrane protein 79	1.08
Zfp143	1	174.70	Protein coding	Zinc finger protein 143	1.07
Piwil2	15	52.04	Protein coding	Piwi-like RNA-mediated gene silencing 2	1.05