Table 1. Cohort information.

This table indicates the number of mice per treatment in each cohort, serum ethanol concentrations (SEC) measured in CIE-exposed mice and the time-point of behavioral testing.

Strain	Cohort	Group sizes	SEC (mg/dL)	Behavioral tests
C57	Cohort 1	Air, n=10 CIE, n=10	211.2 ± 25.0	SAT 6-7 days withdrawal from CIE4 (Fig. 1A-D) DMB 10 days withdrawal from CIE4 (Fig. 3A-C)
	Cohort 2	Air, n=12 CIE, n=7	206.2 ± 17.5	NSF 5 days withdrawal from CIE5 (Fig. 2A-C) BBT 3-7 days withdrawal from CIE6 (Fig. 4A-B)
	Cohort 3	Air, n=4* CIE, n=5	217.5 ± 22.6	NSF 5 days withdrawal from CIE5 (Fig. 2A-C) BBT 3-7 days withdrawal from CIE6 (Fig. 4A-B)
DBA	Cohort 1	Air, n=7 CIE, n=6	253.3 ± 16.0	SAT 6-7 days withdrawal from CIE4 (Fig. 1E-H)
	Cohort 2	Air, n=5 CIE, n=5	179.5 ± 22.3	NSF 5 days withdrawal from CIE4 (Fig. 2D-F) BBT 3-7 days withdrawal from CIE6 (Fig. 4C-D)
	Cohort 3	Air, n=7 CIE, n=5	169.5 ± 19.9	NSF 5 days withdrawal from CIE4 (Fig. 2D-F) DMB 10 days withdrawal from CIE4 (Fig. 3D-F)

CIEn, week n of CIE exposure; SAT, social approach test; NSF, novelty-suppressed feeding; BBT, bottle brush test; DMB, digging and marble burying.

^*one Air male from C57 cohort 3 was excluded from the NSF test because it kept trying to escape from the arena and home cage