Table 3.
Difference in Mean Factor VIII and Protein C Levels by Cardiovascular Risk Factors in the Cohort Random Sample
| Cardiovascular Risk Factor* | Factor VIII (%) | p | Protein C (%) | p |
|---|---|---|---|---|
| Age (per 10 years) | 9 | <0.001 | −2 | <0.001 |
| Male vs. female | −7 | 0.003 | 13 | <0.001 |
| Black vs. white | 11 | <0.001 | −6 | <0.001 |
| Region | - | - | - | - |
| Belt vs Nonbelt | 0.3 | 0.92 | −4 | 0.01 |
| Buckle vs. Nonbelt | 3 | 0.42 | −2 | 0.32 |
| Current Smoking (yes vs. no) | 7 | 0.05 | 0.2 | 0.90 |
| Diabetes (yes vs. no) | 5 | 0.14 | 0.5 | 0.75 |
| Baseline Cardiovascular Disease (yes vs. no) | 18 | <0.001 | −5 | 0.04 |
| Baseline CHD (yes vs. no) | 19 | <0.001 | −5 | 0.04 |
| Baseline Stroke (yes vs. no) | 20 | 0.04 | −4 | 0.21 |
| Atrial Fibrillation (yes vs. no) | 10 | 0.03 | −3 | 0.11 |
| Left Ventricular Hypertrophy (yes vs. no) | 6 | 0.23 | 3 | 0.20 |
| Body Mass Index (per 5kg/m2) | 2 | 0.06 | 0.6 | 0.16 |
| Systolic Blood Pressure (per 10mmHg) | −0.3 | 0.67 | 1 | 0.008 |
| Blood Pressure Medications (yes vs. no | 9 | 0.002 | 2 | 0.05 |
| Total Cholesterol (20 mg/dL increase) | −0.5 | 0.46 | 4 | <0.001 |
| HDL Cholesterol (per 10 mg/dL increase) | −2 | 0.06 | 2 | <0.001 |
| Taking cholesterol medications (yes vs. no) | 0.5 | 0.85 | 5 | <0.001 |
| Loge CRP (per SD (1.21 unit) increase) | 6 | <0.001 | 2 | 0.001 |
| Factor VIII % (per SD increase) | - | - | −1 | 0.36 |
| Protein C % (per SD increase) | −2 | 0.37 | - | - |
*
Adjusted for age, sex, race, and region.