Table 1. Biological processes and pathways related to schizophrenia risk genes overlapping with current drug targets.
The table lists the top five most significant biological processes and pathways from GO enrichment analysis of risk genes ≤1 step from an antipsychotic drug target gene (n=31). For GO terms or pathways with the same risk gene set (complete overlap or one gene set being a subset of the other), we only include the most significant here. Full details are shown in Supplementary Table 2.
| ID | Name | P value |
|---|---|---|
| Biological processes | ||
| GO:0098916 | Anterograde trans-synaptic signaling | 8.05E-08 |
| GO:0007611 | Learning or memory | 2.41E-07 |
| GO:0051130 | Positive regulation of cellular component organization | 3.54E-07 |
| GO:0010628 | Positive regulation of gene expression | 5.66E-07 |
| GO:0050769 | Positive regulation of neurogenesis | 6.56E-07 |
| Pathways | ||
| 477129 (REACTOME) | Developmental Biology | 4.40E-08 |
| 83085 (KEGG) | Long-term potentiation | 6.60E-07 |
| 217716 (KEGG) | Cholinergic synapse | 8.84E-06 |
| 213818 (KEGG) | Glutamatergic synapse | 1.01E-05 |
| 868086 (KEGG) | Rap1 signaling pathway | 1.35E-05 |