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. 2018 Jun 26;13:3689–3711. doi: 10.2147/IJN.S159839

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© 2018 Kramer et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License

The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Z-average diameter (A), pH measurements (B), GLA content (C), and ID93 content (D) for samples stored for 3 months at the indicated temperatures. The six lead formulations (TP, TT, TMP, SMP, SP, and ST), the POC formulation, two-vial clinical presentation, and a liquid single-vial comparator are shown. Error bars indicate the standard deviation of two (D) or three (A and C) measurements.

Abbreviations: GLA, glucopyranosyl lipid adjuvant; TP, trehalose–phosphate; TT, trehalose–Tris; TMP, trehalose–mannitol–phosphate; SMP, sucrose–mannitol–phosphate; SP, sucrose–phosphate; ST, sucrose–Tris; POC, proof of concept.