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. 2018 Jul 2;8:9966. doi: 10.1038/s41598-018-27767-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sensitivity of Ph+ leukemia cell lines to PARP1 inhibitor. (a) Dose-response curve of olaparib sensitivity in Ph+ leukemia cell lines. The vertical axis indicates the percentage (%) viability in the alamarBlue cell viability assay and the horizontal axis indicates log concentration of olaparib (μM). Left and right panels indicate the sensitivities of Ph+ lymphoid and Ph+ myeloid cell lines, respectively. (b) Olaparib sensitivity in 16 Ph+ lymphoid, 4 Ph+ myeloid, and 77 Ph-negative lymphoid leukemia cell lines. The vertical axis indicates the IC₅₀ value of olaparib. The IC₅₀ value of cell lines in each group is also represented by a boxplot.