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. 2018 Jul 2;8:9966. doi: 10.1038/s41598-018-27767-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TKIs and chemotherapeutic agents sensitivities in parental cells and T315I-acquired sublines of three cell lines. (a,b,c) Dose-response curves of nilotinib (a), dasatinib (b), and ponatinib (c) sensitivities in parental cells (blue line) and T315I-acquired sublines (#1 and #2) (red and green lines, respectively) of K562 (upper left), TCCS (upper right), and KOPM28 (lower left). The vertical axis indicates % viability in the alamarBlue cell viability assay and the horizontal axis indicates log concentrations of nilotinib (a), dasatinib (b), and ponatinib (c) (nM). (d) Dose-response curves of AraC (upper) and DNR (lower panel) sensitivities in parental cells (blue line) and T315I-acquired sublines (#1 and #2) (red and green lines, respectively) of TCCS (left) and KOPM28 (right panel). The vertical axis indicates % viability in the alamarBlue cell viability assay and the horizontal axis indicates log concentrations of AraC and DNR.