Table 4.
Top Canonical Pathways Involved in Hyperoxia-Exposed Group by Ingenuity Pathway Analysis (n = 5 in Air group, 6 in Hyperoxia group, P = Hyperoxia vs. Air group).
| Name | P-Value | Overlap (percentage; number of proteins differentially expressed/number of proteins in pathway) |
|---|---|---|
| Mitochondrial dysfunction | 2.94E-33 | 52.0%, 89/171 |
| Regulation of eukaryotic initiation factor 2 (EIF2) signaling | 3.66E-32 | 46.2%, 102/221 |
| Oxidative phosphorylation | 1.16E-23 | 54.1%, 59/109 |
| Regulation eukaryotic initiation factor 4 (EIF4) and ribosomal protein S6 kinase beta-1 (S6K1) signaling | 1.23E-23 | 46.5%, 73/157 |
| PPAR/RXR activation | 9.53E-08 | 28.4%, 52/183 |
| NRF2-mediated oxidative stress response | 1.96E-08 | 26.9%, 66/245 |
| Protein ubiquitination pathway | 1.02E-19 | 35.5%, 94/265 |