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. 2018 Jul 2;8:9975. doi: 10.1038/s41598-018-28195-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Piezo2 localizes to subsets of neuronal endings in the tongue and hard palate. (a) Piezo2 protein was found in sensory endings that surround taste cells in fungiform papillae (arrow). These endings form bulbous end feet that innervate the epidermis. (b) A subset of neuronal endings in filiform papillae were also Piezo2+. These likely represent end bulbs of Krause (arrow). (c) In the hard palate rugae, Piezo2 was localized to glomerular endings (yellow arrow), as well as in K8+ Merkel cells (red arrow). Piezo2+ crescent-shaped structures in the same region could represent K8- Merkel cells or adjacent sensory neuronal terminals (white arrow). (d) Expanded image of a Piezo2+, K8+ Merkel cell and Piezo2+, K8-.