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. 2018 Jul 2;8:9976. doi: 10.1038/s41598-018-28349-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic tree of DENV-2 isolated from the 2015 outbreak in Guangdong, China. Sixty-one E gene sequences from isolated strains and 245 reference sequences from GenBank were used for the phylogenetic tree reconstructions. Six genotypes were assigned according to previous studies. One cluster (n = 60) was assigned to the Cosmopolitan genotype of DENV-2. The extra isolates also belonged to this genotype but were not clustered together with the other sixty isolates. The outbreak isolates are indicated by blue circles, and the isolates from the imported cases are indicated by red circles.