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. 2018 Jul 2;8:9928. doi: 10.1038/s41598-018-27640-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KLK8 knockdown in vitro and in vivo in mouse hippocampus markedly reduced microtubule associated dendrite growth and spine density. (A) Western blot analysis showing reduced L1CAM cleavage and MAP2c level and (B) dendrite growth in primary hippocampal neurons upon KLK8 gene silencing. ‘*’ Denotes significant differences (p < 0.05) as compared to control. Silencer® Negative siRNA with scrambled sequence was used as a negative control along with another control cells treated only with lipofectamine. (C) Hippocampal KLK8 mRNA expression, MAP2c level and (D) Golgi staining based dendrite spine density upon KLK8 knockdown by antisense oligonucleotides ‘*’ denotes significant differences as compared to sham control.