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. 2018 Jul 2;8:124. doi: 10.1038/s41398-018-0171-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A significant genotype by CUS interaction was observed on two-way ANOVA, demonstrating that CUS-exposed Ahi1+/+ mice displayed an attenuated freezing response to the conditioning chamber following fear training compared to Ahi1+/+ controls and CUS-exposed Ahi1+/− mice (F[1,66] = 7.192, p = 0.009). Post hoc tests of simple main effects with Bonferroni correction indicated that CUS-exposed Ahi1+/+ mice displayed diminished freezing response to the conditioned context compared to both CUS-exposed Ahi1+/− mice (p < 0.05) and Ahi1+/+ controls (p < 0.05). There was no significant difference between CUS-exposed Ahi1+/− mice and Ahi1+/− control mice. No significant differences were observed on cued freezing response to the conditioned tone. *p < 0.05