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. 2018 Jul 2;150(7):969–976. doi: 10.1085/jgp.201812017

Figure 7.

Figure 7.

SpTx-1 sensitivity of Kir6.2 containing PNDM-causing mutations. (A) Currents of Kir6.2 with individual PNDM-causing mutations on the ΔC26 background without (black trace) or with (red trace) the presence of 10 nM recombinant SpTx-1. (B) Fractions of current, recorded from the Kir6.2-ΔC26 mutant channels with or without these PNDM-causing mutations, are plotted against the concentration of SpTx-1. The Kd values determined from the curve fitting are in nM: 8.5 ± 0.37 (Kir6.2-ΔC26 itself), 13.0 ± 3.5 (Q52R), 21 ± 2 (V59G), 11.6 ± 0.9 (R201C), 5.8 ± 0.8 (R201H), 11.3 ± 0.6 (I296L), and 11.6 ± 1.2 (G334D). n = 6–10. Data represent the mean ± SEM.