Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 2;150(7):949–968. doi: 10.1085/jgp.201711868

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Khalili-Araghi et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 16. — D55 is a key amino residue that defines claudin-15 cation selectivity. (A–D) I-V curves were calculated for systems containing 110-mM NaCl solutions for D55N (A), D55K (B), D64K (C), and triple mutation of E46K/D55K/D64K (D). The cationic and anionic currents are shown in blue and red, respectively. (E) Conductance of claudin-15 pores for Na⁺ and Cl⁻ ions obtained from simulation trajectories of the mutants and WT demonstrates the importance of D55. Error bars for the total conductance represent the statistical error in estimating the total conductance from finite number of permeation events.