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. 2018 Jul 2;150(7):949–968. doi: 10.1085/jgp.201711868

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© 2018 Khalili-Araghi et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 19. — The selectivity filter, located near the center of the claudin-15 pore, has a high affinity for Na⁺ ions. (A and B) Cross sections of the claudin-15 pore across the planes parallel (A) or perpendicular (B) to the membrane. Protein surface is shown in van der Waals representation. The residues lining the pore are colored based on their contact time with permeating Na⁺ ions as shown in Fig. 13 A.