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. 2018 Jul 2;150(7):1003–1015. doi: 10.1085/jgp.201812016

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© 2018 Yamada and Strange

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Figure 8. — PONDR VLXT analysis of LRRC8A (black) and LRRC8C (red) ILs. PONDR scores are aligned with specific amino acid residues, which are shown at the top. The dashed box shows amino acid sequences that diverge significantly in LRRC8A, LRRC8C, LRRC8D, and LRRC8E proteins (Fig. 2). Amino acids colored green (D182–E206) in the LRRC8A sequence are the minimal sequence required to give rise to chimeric homomeric 8C-8A(IL) and 8E-8A(IL) VRACs with normal swelling-induced activity.