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. 2018 Jul 2;215(7):1913–1928. doi: 10.1084/jem.20171960

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© 2018 Saei et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 3. — USP28 is down-regulated in melanoma and confers poor prognosis. (A) Oncomine box plot of USP28 in melanoma. (B) Matrix heat map generated using cBioportal showing genetic alterations of BRAF, NRAS, NF1, USP28, and FBW7 in melanoma patients (n = 287; TCGA). (C) Beeswarm plot demonstrating relative copy number variation of USP28 in melanoma patients, along with their respective mutational status of BRAF (blue), NRAS (red), NF1 (green), and USP28 (X) genes, respectively (n = 118). (D) Kaplan-Meier curves showing probability of overall survival of melanoma patients with lower copy number of USP28 is significantly less than those with higher level of USP28 (P = 0.05; HR = 8.15). (E) Kaplan-Meier curves showing probability of tumor free survival of melanoma patients with low levels of USP28 is significantly less than those with high levels of USP28 (P = 0.0065; HR = 14.45). (F) Kaplan-Meier survival analysis of melanoma patients harboring BRAF V600E mutation in respect to expression of USP28. Lower expression of USP28 confers poorer overall survival to melanoma patients carrying BRAF 600E mutation (P = 0.046; HR = 3.8).