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. 2018 Jun 26;12:238. doi: 10.3389/fnhum.2018.00238

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Copyright © 2018 Sneider, Cohen-Gilbert, Hamilton, Stein, Golan, Oot, Seraikas, Rohan, Harris, Nickerson and Silveri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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During fMRI vMWT performance: (A) Regions showing significant increases in brain activation (red–yellow, p < 0.05 corrected) during retrieval/hidden trials (with room cues) relative to motor/visible trials (with no room cues). (B) Regions showing significantly greater activation (blue–light blue, p < 0.05 corrected) during motor/visible trials relative to retrieval (hidden platform) trials. For reference, the hippocampus region of interest from the Harvard-Oxford Subcortical Structure Atlas threshold at 30% is shown in green. (C) Mean % BOLD signal change for retrieval/hidden > rest (solid bars with black cross hatch) and motor/visible > rest (solid bars) extracted from hippocampus (HIPP), middle frontal gyrus (MFG), anterior cingulate cortex (ACC), and frontal medial cortex (FMC). Orange indicates increased BOLD signal, blue indicates decreased BOLD signal.