Table 2. Effects of Khc knockdown and mutations on dendrite arborization.

Measurement	Control	Khc-RNAi	E177K	S246F	S246F + E177K
Critical radius	178 ± 16	148 ± 30**	141 ± 33**	169 ± 12 (NS)	154 ± 14*
Maximum branches	61 ± 6	49 ± 9***	39 ± 6****	57 ± 8 (NS)	61 ± 9 (NS)

Sholl analysis of dendritic arbors quantifies the number of dendrites that intersect concentric circles centered on the cell body. The radius of the circle with the maximum dendritic intersections is the critical radius and the intersections at this radius are the maximum number of branches. Mean ± SD for both measurements; n (neurons) = 14 control, 16 Khc-RNAi, 10 Khc^E177K, 14 Khc^S246F, 11 Khc^S246F,E177K. *, P = 0.05–0.01; **, P = 0.01-0.001; ****, P < 0.0001 in comparison with control and evaluated by one-way ANOVA with Tukey post hoc test.