Figure 2.

p53 is deregulated in dysplasia patient samples. The mutational status of p53 in dysplasia and adjacent metaplasia samples (cohort 2) was determined by NGS. The positions and frequency of the mutations identified in each patient in metaplasia and dysplasia areas are shown above and below the protein schematic, respectively. fs, frameshift mutation; OD, oligomerization domain; RD, regulatory domain; TD, transactivation domain. The asterisk indicates a nonsense mutation.