Table 1.
Promoting factors | Selection | Specification |
Effector differentiation |
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NKT1 | NKT2 | NKT17 | |||
ROR-γt | PLZF | CD122/IL-15 | IL-17RB/IL-25 ? | TGF-βRII/TGF-β | |
HEB | Runx1 | Let-7 | Lin28 | ||
c-Myc | CUL3 | Pak2 | |||
c-Myb | CCR7/CCL21a | Hobit | T cell receptor (TCR) binding half-life | ||
SLAMF1 and SLAMF2 | Egr2 | UTX | KLF13 | ||
miR-181a | NKAP | T cell factor 1 | |||
TCR signaling strength | Histone deacetylase 3 |
Lymphoid enhancer factor 1 (preferentially promote NKT2) | |||
Dicer/microRNAs | |||||
Inhibitory factors | Lin28 | Let-7 | |||
TCR binding half-life | Kruppel-like factor 2 | TET2/TET3 | |||
Jarid2 |
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Ezh2 |