Table 1.
Genetic factors influence development of iNKT subsets.
| Promoting factors | Selection | Specification |
Effector differentiation |
||
| NKT1 | NKT2 | NKT17 | |||
| ROR-γt | PLZF | CD122/IL-15 | IL-17RB/IL-25 ? | TGF-βRII/TGF-β | |
| HEB | Runx1 | Let-7 | Lin28 | ||
| c-Myc | CUL3 | Pak2 | |||
| c-Myb | CCR7/CCL21a | Hobit | T cell receptor (TCR) binding half-life | ||
| SLAMF1 and SLAMF2 | Egr2 | UTX | KLF13 | ||
| miR-181a | NKAP | T cell factor 1 | |||
| TCR signaling strength | Histone deacetylase 3 |
Lymphoid enhancer factor 1 (preferentially promote NKT2) | |||
| Dicer/microRNAs | |||||
| Inhibitory factors | Lin28 | Let-7 | |||
| TCR binding half-life | Kruppel-like factor 2 | TET2/TET3 | |||
| Jarid2 |
|||||
| Ezh2 | |||||