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. 2018 Jun 26;12:175. doi: 10.3389/fncel.2018.00175

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Copyright © 2018 Hong, Wang, Lu, Zorio, Wang and Sanchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resurgent Na_V current (I_NaR) of NMc neurons. (A–C) Representative current traces in response to voltage-clamp protocols that elicit I_NaR (if any) shown below traces. The amplitude of the conditioning step is +30 mV in (A), 0 mV in (B) and –30 mV in (C). The duration of the conditioning step is 10 ms. (D) Population data showing the I_NaR amplitude plotted as a function of repolarizing membrane voltage (V_MEMBRANE) for NMc neurons, in response to the conditioning step shown in (A,B). (E,F) Population data showing the I_NaR time to peak (E) and decay time constant (tau, F) as a function of repolarizing membrane voltage (V_MEMBRANE), in response to conditioning step of +30 mV. Error bar = standard error.