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. 2018 Jun 26;5:59. doi: 10.3389/fmolb.2018.00059

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Copyright © 2018 Datta and Brosh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall structure of the taXPD-DNA complex. Shown are the two RecA-like domains in yellow orange and ruby, the FeS cluster domain in deep teal, and the Arch domain in forest green. The DNA is shown in orange/yellow/blue. The Arch and Fe-S domains, both implicated in strand separation and only found in Fe-S helicases, are proposed sites for docking small molecules to modulate helicase function. Image was modified from one kindly provided by Drs. Jochen Kuper and Caroline Kisker, University of Wuerzburg.