Table 2.
Associations between kidney injury measurements and MRI markers of CSVD.
| log-WMHV | Lacunes | BPF | ||||
|---|---|---|---|---|---|---|
| β ± SE | p | OR (95% CI) | p | β ± SE | p | |
| Log-ACR | ||||||
| Model 1 | 0.16 ± 0.05 | 0.001 | 1.43(1.19,1.70) | 0.000 | −0.02 ± 0.07 | 0.785 |
| Model 2 | 0.11 ± 0.05 | 0.034 | 1.27 (1.05, 1.54) | 0.014 | −0.03 ± 0.07 | 0.705 |
| Model 3 | 0.06 ± 0.05 | 0.279 | 1.28 (1.04, 1.58) | 0.018 | −0.09 ± 0.08 | 0.597 |
| Model 4 | 0.13 ± 0.05 | 0.017 | 1.35 (1.10, 1.66) | 0.004 | −0.05 ± 0.08 | 0.551 |
| eGFR | ||||||
| Model 1 | −0.03 ± 0.06 | 0.578 | 0.77(0.62,0.96) | 0.017 | 0.24 ± 0.09 | 0.009 |
| Model 2 | −0.03 ± 0.06 | 0.595 | 0.77(0.61, 0.96) | 0.023 | 0.27 ± 0.09 | 0.003 |
| Model 3 | −0.02 ± 0.06 | 0.809 | 0.78 (0.62, 0.99) | 0.040 | 0.26 ± 0.10 | 0.007 |
| Model 4 | −0.06 ± 0.07 | 0.404 | 0.74 (0.58, 0.94) | 0.014 | 0.33 ± 0.10 | 0.001 |
Model 1: adjustment for age and sex.
Model 2: as in Model 1, with additional adjustment for vascular risk factors (hypertension, diabetes, hyperlipidemia, current smoking, and BMI).
Model 3 and Model 4: as in Model 2, with additional adjustment for baPWV and carotid plaque separately. Analyses involving white matter hyperintensity volume were additionally adjusted for intracranial volume.
ACR, albumin-to-creatinine ratio in urine; eGFR, estimated glomerular filtration rate; WMHV, white matter hyperintensity volume; BPF, brain parenchymal fraction.