Table 3.

Interactions between Carotid plaques, BaPWV, Kidney injury measurements, and CSVD MRI Markers.

	log-WMH		lacunes		BPF		CMBs
	Beta (std.)	p	OR (95% CI)	p	Beta (std.)	p	OR (95% CI)	p
MODEL 1
ACR	−0.062	0.643	4.18 (1.45, 12.08)	0.008	0.138	0.261	1.43 (0.46, 4.44)	0.538
baPWV	0.130	0.000	1.00 (1.00, 1.01)	0.051	−0.053	0.096	1.00 (1.00, 1.01)	0.301
ACR × baPWV	0.096	0.477	0.99 (0.99, 1.00)	0.027	−0.161	0.193	1.00 (0.99, 1.01)	0.688
MODEL 2
ACR	0.001	0.985	1.56 (1.06, 2.29)	0.023	−0.046	0.222	1.03 (0.65, 1.63)	0.908
carotid plaque	0.063	0.054	2.08 (1.22, 3.55)	0.007	−0.103	0.000	1.42 (0.80, 2.51)	0.226
ACR × carotid plaque	0.091	0.035	0.82 (0.53, 1.29)	0.391	0.024	0.521	1.14 (0.68.1.94)	0.616
MODEL 3
eGFR	−0.060	0.646	0.26 (0.09, 0.79)	0.017	−0.274	0.023	0.60 (0.20, 1.84)	0.373
baPWV	0.144	0.000	1.01 (1.01, 1.02)	0.012	−0.034	0.284	1.01 (1.00.1.01)	0.201
eGFR × baPWV	0.054	0.681	1.01 (1.00, 1.01)	0.047	0.363	0.002	1.00 (1.00, 1.01)	0.559
Model 4
eGFR	−0.002	0.722	0.69 (0.44, 1.07)	0.095	−0.10	0.825	0.83 (0.53, 1.29)	0.397
carotid plaque	0.063	0.053	2.12 (1.25, 3.60)	0.005	−0.114	0.000	1.42 (0.81, 2.51)	0.221
eGFR × carotid plaque	−0.013	0.766	1.10 (0.68, 1.79)	0.698	0.136	0.001	0.98 (0.60, 1.61)	0.943

Model 1, Model 2, Model 3, Model 4 were adjusted for age, sex and vascular risk factors (hypertension, diabetes, hyperlipidemia, current smoking, and BMI). Analyses involving white matter hyperintensity volume were additionally adjusted for intracranial volume.

ACR, albumin-to-creatinine ratio in urine; eGFR, estimated glomerular filtration rate; WMHV, white matter hyperintensity volume; BPF, brain parenchymal fraction.