Table 3.

Nominally significant SNP associations for relative changes in biomarkers.

Pathway	SNP	Gene	aCPB	pCPB	24H
S100β vs. BL
2nd mess cell signaling	rs198388	NPPB		x
2nd mess cell signaling	rs4477886	ROCK2			x
Acid base cell vol regulation	rs4973768	SLC4A7			x
Apoptotic factors	rs3749166	CAPN10		x	x
Estrogen	rs4986938	ESR2	x
Inflammation	rs2228145	IL6R			x
Inflammation	rs2227631	SERPINE1		x
Inflammation	rs1640827	TLR5	x
Inflammation	rs1800629	TNF	x	x
Neurotransmitters	rs1801253	ADRB1	x
Neurotransmitters	rs211014	GABRG2		x
Platelets and coagulation	rs2070011	FGA			x
Protein chaperone repair	rs1617640	EPO	x		x
Protein chaperone repair	rs2763979	HSPA1B			x
NFH vs. BL
2nd mess cell signaling	rs10061804	NPR3		x
Acid base cell vol regulation	rs9951307	AQP4		x
Apoptotic factors	rs1805419	BAX			x
Apoptotic factors	rs3900115	CASP10	x
Apoptotic factors	rs3769827	CASP8	x
Apoptotic factors	rs937283	MDM2	x	x
Calcium regulation	rs815815	CALM2		x
Inflammation	rs1126757	IL11	x
Inflammation	rs2298885	IL11	x		x
Inflammation	rs230529	NFKB1		x
Inflammation	rs5361	SELE	x		x
Inflammation	rs237025	SUMO4		x	x
Inflammation	rs1866389	THBS4	x
Neurotransmitters	rs553668	ADRA2A			x
Neurotransmitters	rs1461225	GRIA1		x
Other	rs10423702	NOTCH3	x
Peroxidation	rs6917589	SOD2		x	x
Platelets/Coagulation	rs1654431	GP6		x
Vascular regulation	rs1042713	ADRB2			x

x- P < 0.05 for association without correction for multiple comparisons. Blood samples were drawn immediately after induction of anesthesia (baseline-BL), just prior to CPB (aCPB), 1 h after the end of CPB (pCPB), and 24 h (24 H) postoperatively.