Table 4.

Regression data: change in biomarkers from BL: pCPB and 24H.

Variable	Coefficient	Std. Error	t-value	p-value	Gene
NFH (EQUATION 1) CHANGE AT pCPB
(Intercept)	−0.24	0.10	−2.36	2.25e-02	NA
rs6917589	−0.20	0.06	−3.29	1.95e-03	SOD2
rs237025	0.11	0.05	2.22	3.14e-02	SUMO4
rs1654431	0.10	0.05	2.10	4.12e-02	GP6
rs815815	−0.09	0.06	−1.45	1.53e-01	CALM2
rs937283	−0.09	0.06	−1.47	1.50e-01	MDM2
rs230529	0.08	0.05	1.64	1.07e-01	NFKB1
S100β (EQUATION 2) CHANGE AT pCPB
(Intercept)	2.38	0.35	6.80	6.34e-09	NA
rs1800629	0.57	0.27	2.09	4.15e-02	TNF
rs3749166	0.55	0.21	2.57	1.28e-02	CAPN10
rs198388	−0.50	0.21	−2.40	1.97e-02	NPPB
rs2227631	0.43	0.19	2.23	2.99e-02	SERPINE1
NFH (EQUATION 3) CHANGE AT 24H
(Intercept)	−1.34	0.30	−4.42	8.09e-05	NA
rs553668	0.28	0.12	2.39	2.20e-02	ADRA2A
rs5361	−0.21	0.10	−2.05	4.77e-02	SELE
rs1805419	0.21	0.10	2.17	3.61e-02	BAX
rs237025	0.17	0.08	1.99	5.37e-02	SUMO4
rs2298885	0.13	0.10	1.37	1.80e-01	IL11
rs1042713	0.13	0.09	1.48	1.47e-01	ADRB2
rs6917589	0.13	0.09	1.38	1.77e-01	SOD2
First ICU Glc	4.42e−03	1.71e-03	2.59	1.35e-02	NA
S100β (EQUATION 4) CHANGE AT 24H
(Intercept)	−1.50	0.87	−1.73	9.06e-02	NA
rs4973768	0.57	0.22	2.53	1.46e-02	SLC4A7
rs2763979	0.55	0.21	2.60	1.21e-02	HSPA1B
rs2070011	−0.50	0.23	−2.17	3.45e-02	FGA
rs3749166	0.40	0.21	1.94	5.85e-02	CAPN10
rs4477886	0.40	0.22	1.83	7.29e-02	ROCK2
rs1617640	−0.29	0.22	−1.32	1.92e-01	EPO
Age	0.02	0.01	2.31	2.50e-02	NA