Table 2.
Top sites showing MIA and n-3 induced differential methylation
| n-6-SAL vs n-6-POL | n-3-POL vs n-6-POL | |||||
|---|---|---|---|---|---|---|
| Gene name | Distance to the gene | q -value | Δmethylation % | q -value | Δmethylation % | CpG sites |
| Sfi1 | 16 | < 1.10 × 10−16 | −26.7 to −6.59 | 7.18 × 10−14 | −23.48 to −5.1 | 9 |
| Sox17 | −62863 | < 1.10 × 10−16 | 10.54 to 18.23 | 2.58 × 10−13 | 9.58 to 16.02 | 6 |
| Pex2 | −284438 | < 1.10 × 10−16 | −17.17 to 14.54 | 2.60 × 10−11 | −10.92 to 10.31 | 5 |
| Oprk1 | −237706 | < 1.10 × 10−16 | 13.94 to 18.02 | 1.38 × 10−10 | 10.17 to 13.84 | 2 |
| Cerk | −9086 | < 1.10 × 10−16 | −30.08 to −26.79 | < 1.10 × 10−16 | −23.16 | 1 |
| Erdr1 | −1137.5 | < 1.10 × 10−16 | −30.08 to −26.79 | 4.11 × 10−13 | −27.73 to −20.44 | 2 |
| Eya1 | 196687 | < 1.10 × 10−16 | 16.01 to 24.08 | 1.30 × 10−11 | 10.50 to 18.79 | 2 |
| Filip1l | 38241 | < 1.10 × 10−16 | 7.87 | 3.07 × 10−13 | 6.6 | 1 |
| G530011O06Rik | −30472 | < 1.10 × 10−16 | −34.15 to −32.87 | < 1.10 × 10−16 | −31.52 to −24.74 | 2 |
| Gm15386 | −272508 | < 1.10 × 10−16 | 9.02 to 13.29 | 1.36 × 10−13 | 8.86 to 11.66 | 2 |
| Pi15 | −134875 | < 1.10 × 10−16 | 15.12 | < 1.10 × 10−16 | 12.57 | 1 |
| Rn45s | 2643 | < 1.10 × 10−16 | −13.6 to 15.71 | 1.03 × 10−11 | −10.53 to −7.62 | 3 |
| B020004J07Rik | −27301 | 1.44 × 10−13 | −32.83 | 0.001 | −19.01 | 1 |
| 3110070M22Rik | −120 | 2.03 × 10−13 | −9.74 to 9.93 | 1.03 × 10−9 | −7.79 to 4.61 | 3 |
| Zbtb24 | −12896 | 1.49 × 10−11 | −30.62 | 0.028 | −14.75 | 1 |
| Gm10377 | 82454 | 9.70 × 10−10 | 26.22 | 5.86 × 10−4 | 18.25 | 1 |
| Gm5415 | −472527 | 1.50 × 10−9 | 9.34 | 6.09 × 10−7 | 8.23 | 1 |
| 4930515L03Rik | −71170 | 2.40 × 10−9 | 28.79 | 0.166 | 10.06 | 1 |
| 1700030C10Rik | 582097 | 3.59 × 10−9 | −11.27 | 0.001 | −7.67 | 1 |
| 2900097C17Rik | 29994 | 4.24 × 10−9 | −28.16 | 0.003 | −18.63 | 1 |
| Itgbl1 | 11323 | 3.08 × 10−8 | 26.72 | 0.022 | 15.49 | 1 |
| Plcd3 | 17139 | 6.12 × 10−8 | −29.14 | 0.004 | −21.17 | 1 |
| Gm17026 | 54903 | 1.06 × 10−7 | 23.73 | 0.002 | 17.17 | 1 |
| Rpia | 703669 | 1.24 × 10−7 | 22.35 | 1.81 × 10−4 | 17.75 | 1 |
| Mir684-1 | −41569 | 1.56 × 10−7 | −26.42 | 0.001 | −20.93 | 1 |
| 9330188P03Rik | 196 | 2.15 × 10−7 | −24.76 | 0.152 | −10.96 | 1 |
| Zp3r | 28668 | 4.36 × 10−7 | 27.79 | 0.025 | 18.48 | 1 |
| Ppp1r15b | 40280 | 7.88 × 10−7 | −27.33 | 0.002 | −19.61 | 1 |
List of top differentially methylated genes. n-6-SAL vs n-6-POL comparison lists the MIA effect, n-3-POL vs n-6-POL comparison lists the n-3 effect. Average distance from the CpG sites to the nearest gene, q-value—BH corrected p-value, Δmethylation—difference in methylation in percentages listed as a range, number of differentially methylated CpG sites are listed in the gene. The lowest q-value among the differentially methylated CpG sites is listed