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. 2018 Jul 2;9:2570. doi: 10.1038/s41467-018-04985-0

Fig. 7.

Fig. 7

Human mo-DCs, but not mo-Mac, provide co-stimulatory signals for the differentiation of cytotoxic CD8+ T cells. a Heatmap of scaled expression for selected co-stimulation genes. d donor. b Purified DCs and macrophage from tumor ascites were cultured with allogeneic naïve CD4+ T cells for 7 days, in the presence of naïve CD8+ T cells. Total number of live CD4+ T cells at the end of the culture is depicted. N = 8. c Purified DCs and macrophage from tumor ascites were cultured in the absence or presence of CD40-L, IFN-γ, and R848 for 24 h. Secretion of IL-12p70 was measured in the supernatant. N = 5. b, c Symbols represent individual donors. Median is shown. ** p < 0.01, Wilcoxon non-parametric test