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. 2018 Jun 26;9:273. doi: 10.3389/fpsyt.2018.00273

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Copyright © 2018 Rangaprakash, Bohon, Lawrence, Moody, Morfini, Khalsa, Strober and Feusner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regions of interest and dynamic effective connectivity findings: (A) Regions-of-interest: bilateral medial prefrontal cortex (mPFC), rostral anterior cingulate cortex (rACC) and amygdala. (B) Significant connections identified in each of the three groups as increasing from block1 to block2 to block3 during the presentation of fearful face stimuli. This figure shows the evidence we found for all our three hypotheses. As predicted, there was bidirectional connectivity between mPFC and amygdala in HCs, unidirectional mPFC-to-amygdala connectivity in BDD, and no significant prefrontal-amygdala connectivity in AN.